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Preventing & delaying T1D

Finding T1D early — and the therapies that delay it.

Screening that catches T1D before symptoms, and the immune therapies that slow or delay its onset — each scored 0–100 against published, category-specific criteria including effect size, durability, safety, and clinical maturity. Every row shows where it sits in the pipeline, when and where it is available, and the headline result. Expand for the full scorecard and primary sources.

11 screening pathways  ·  reviewed Jun 2026

Tests that catch T1D before symptoms — autoantibody and risk screening — ranked on predictive value, actionability, and reach.

01
T1Detect (Breakthrough T1D at-home autoantibody screening)ScreeningStrong evidence

Screening, opened to everyone. A low-cost, at-home finger-prick kit that opens autoantibody screening to the general public.

Pipeline

In clinical use

Available

Available now

Where

US (mail-in)

Headline result

Cuts DKA at diagnosis to <5%

84.5
Details +
02
ELSA (EarLy Surveillance for Autoimmune diabetes)ScreeningStrong evidence

A UK research programme testing whether childhood general-population screening for islet autoantibodies is feasible and acceptable at national scale.

Pipeline

Approved

Available

Available now

Where

UK

81.5
Details +
03
Fr1da (Bavarian General-Population T1D Screening)ScreeningStrong evidence

The pioneering general-population screening program that tests young children for multiple islet autoantibodies during routine pediatric visits — no family history required — to ca

Pipeline

Approved

Available

Available now

Where

EU

78.15
Details +
04
Islet autoantibody screening (GADA, IA-2A, ZnT8A, IAA)ScreeningStrong evidence

The foundation of prevention. A blood panel for the four islet autoantibodies — the foundation of every prevention pathway.

Pipeline

In clinical use

Available

Available now

Where

Global (labs)

Headline result

2+ antibodies = ~84% 15-yr risk

76.25
Details +
05
PLEDGE (Sanford general-population screening)ScreeningStrong evidence

A large US screening program from Sanford Health that tests children for the early immune markers of Type 1 diabetes (and celiac disease) during routine pediatric care, with the ai

Pipeline

Approved

Available

Available now

Where

US

75.95
Details +
06
Type1Screen (Australia)ScreeningStrong evidence

Australia's national islet-autoantibody screening program, coordinated from Royal Melbourne Hospital, offering free in-home finger-prick blood-spot testing to people with a family

Pipeline

Approved

Available

Available now

Where

AU

75.9
Details +
07
ASK (Autoimmunity Screening for Kids)ScreeningStrong evidence

A general-population childhood screening program in Colorado that tests for islet autoantibodies regardless of family history — the model for catching most future T1D, since the gr

Pipeline

Approved

Available

Available now

Where

US

75.25
Details +
08
CASCADE (Cascade Kids newborn screening)ScreeningModerate evidence

A Washington-state program that screens for Type 1 diabetes and celiac risk using leftover newborn-screening blood spots, so families get a risk estimate with no extra blood draw,

Pipeline

Approved

Available

Available now

Where

US

74.4
Details +
09
TrialNet Pathway to PreventionScreeningStrong evidence

Free screening for relatives. Free autoantibody screening and long-term monitoring for relatives of people with T1D.

Pipeline

In clinical use

Available

Available now

Where

US · intl sites

Headline result

Free screening for relatives

73.25
Details +
10
Oral glucose tolerance test (OGTT) for T1D stagingScreeningStrong evidence

The metabolic staging test that turns a positive autoantibody screen into an actionable stage-1 vs stage-2 risk assessment.

Pipeline

Approved

Available

Available now

Where

US · UK · EU · CA · AU · JP · OTHER

70
Details +
11
Genetic risk score (GRS) newborn screeningScreeningModerate evidence

A polygenic + HLA risk score, often run on a newborn blood spot, that flags the small fraction of infants at elevated lifetime T1D risk — before any autoantibody appears — so they

Pipeline

Phase 2

Available

Years away

Where

EU · UK · US · OTHER

64
Details +

Teplizumab (Tzield) is the first therapy proven to delay clinical T1D. Same scoring as Cure, Living and Trials. Science journalism, not medical advice.