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type1.science
Phase 1RecruitingNCT05973734

Islet transplantation with recipient Tregs or donor bone marrow

Trial testing donor-islet transplantation combined with recipient regulatory T cells or deceased-donor vertebral bone marrow therapy to improve immune tolerance.

Primary endpoints

  • Occurrence of Grade 3 to 5 cytokine release syndrome / acute infusion reaction after Treg administration infusion reaction after Treg administration
  • Occurrence of grade 4 or greater adverse events of islet transplantation
  • Number of patients who receive Treg infusions (Arm1) or Donor Derived Vertebral Bone Marrow (Arm2) and islet transplantation (feasibility)

Results so far

No results posted yet.