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Phase 2Active, not recruitingNCT05743244

JAKPOT T1D: Abrocitinib and ritlecitinib in new-onset T1D

TrialNet/NIDDK phase-2 trial comparing two selective oral JAK-pathway drugs - abrocitinib and ritlecitinib - with placebo for preservation of C-peptide in newly diagnosed T1D.

Primary endpoints

  • C-peptide preservation in new-onset T1D

Results so far

No results posted as of 8 August 2026. Recruitment is closed and the estimated 30 June 2026 primary-completion date has passed; full study completion remains estimated for 30 June 2027.

The full picture

JAKPOT is the TrialNet companion to the baricitinib story: a test of whether more selective oral JAK-pathway drugs can reproduce C-peptide preservation with an acceptable safety profile.