16 September 2026 editorial review · Item
Mixed haematopoietic chimerism (immune tolerance induction): review notes
These notes document the scope actually reviewed, including source-access limits. They are not independent clinical certification or a guarantee that every claim was verified.
Read the item evidence page →Preventing and curing evidence review — 16 September 2026
- Disposition: reviewed; no confirmed content change. Current item
lastReviewed: 2026-08-27. - Claim check: Mixed-chimerism mouse work and the MDR-101 kidney RCT address different questions. The 75% immunosuppression-free endpoint in kidney recipients is not human T1D efficacy. The closest islet/bone-marrow registry does not establish successful drug withdrawal.
- Registry NCT05973734: ENROLLING_BY_INVITATION; updated 2026-06-08; enrollment 24 (ESTIMATED); primary completion 2030-12 (ESTIMATED); results not posted in retrieved record.
- Primary publication/regulatory sources checked or consulted: PMID 39922283; PMID 39800883; PMID 39922283; PMID 39800883.