16 September 2026 editorial review · Trial
CLOSE IT: open-source AID without meal announcement vs hybrid closed loop: review notes
These notes document the scope actually reviewed, including source-access limits. They are not independent clinical certification or a guarantee that every claim was verified.
Read the trial evidence page →Baseline trial evidence review: A–H
Outcome: Removed retired roadmap links; checked registry/endpoints or accessible primary abstract. Full results/safety tables were not accessible; no new efficacy inferred.
Registry: ACTRN12622001400752. Accessible primary literature: Glycemic Outcomes During Outpatient Use of Automated Insulin Delivery Without Meal Announcement in Adults with Type 1 Diabetes: Results from the CLOSE IT Randomized Controlled Trial.. Limits: Primary abstract findings were available; supplementary tables and full adverse-event adjudication were not comprehensively re-reviewed. Registry eligibility is not a claim of current site availability. Specific unresolved access limit: The accessible primary abstract supports 73 randomized participants and adjusted −2.2 percentage-point TIR difference (95% CI −6.2 to 1.7). It does not expose detailed hypoglycemia/DKA tables or establish a general safety conclusion. Full report device configuration and noninferiority-margin detail were not independently verified.